| 5 Nov | Jacksonville 57 | at | Xavier 76 | vs ASUN | ||
| 8 Nov | Siena 63 | at | Xavier 81 | vs MAAC | ||
| 12 Nov | Missouri 58 | at | Xavier 63 | OT | vs SEC | |
| 15 Nov | Missouri St 56 | at | Xavier 59 | vs MVC | ||
| 21 Nov | Xavier 73 | vs | Towson 51 | Charleston, SC | vs CAA | |
| 22 Nov | Xavier 75 | vs | Connecticut 74 | 2 OT | Charleston, SC | vs AAC |
| 24 Nov | Florida 70 | vs | Xavier 65 | Charleston, SC | vs SEC | |
| 30 Nov | Lipscomb 62 | at | Xavier 87 | vs ASUN | ||
| 4 Dec | WI Green Bay 71 | at | Xavier 84 | vs HL | ||
| 7 Dec | Cincinnati 66 | at | Xavier 73 | vs AAC | ||
| 14 Dec | Xavier 78 | at | Wake Forest 80 | at ACC | ||
| 18 Dec | W Carolina 61 | at | Xavier 74 | vs SC | ||
| 22 Dec | Xavier 67 | at | TCU 59 | at B12 | ||
| 30 Dec | Xavier 62 | at | Villanova 68 | |||
| 5 Jan | St John's 67 | at | Xavier 75 | |||
| 8 Jan | Seton Hall 83 | at | Xavier 71 | |||
| 11 Jan | Creighton 77 | at | Xavier 65 | |||
| 15 Jan | Xavier 65 | at | Marquette 85 | |||
| 22 Jan | Georgetown | at | Xavier | |||
| 26 Jan | Xavier | at | Creighton | |||
| 29 Jan | Marquette | at | Xavier | |||
| 1 Feb | Xavier | at | Seton Hall | |||
| 4 Feb | Xavier | at | DePaul | |||
| 8 Feb | Providence | at | Xavier | |||
| 12 Feb | Xavier | at | Butler | |||
| 17 Feb | Xavier | at | St John's | |||
| 22 Feb | Villanova | at | Xavier | |||
| 25 Feb | DePaul | at | Xavier | |||
| 1 Mar | Xavier | at | Georgetown | |||
| 4 Mar | Xavier | at | Providence | |||
| 7 Mar | Butler | at | Xavier |
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